I'm the author of Airpocalypse, a medical thriller


Welcome to the digital era of biology (and to this modest blog I started in early 2005).

To cure many diseases, like cancer or cystic fibrosis, we will need to target genes (mutations, for ex.), not organs! I am convinced that the future of replacement medicine (organ transplant) is genomics (the science of the human genome). In 10 years we will be replacing (modifying) genes; not organs!


Anticipating the $100 genome era and the P4™ medicine revolution. P4 Medicine (Predictive, Personalized, Preventive, & Participatory): Catalyzing a Revolution from Reactive to Proactive Medicine.


I am an early adopter of scientific MOOCs. I've earned myself four MIT digital diplomas: 7.00x, 7.28x1, 7.28.x2 and 7QBWx. Instructor of 7.00x: Eric Lander PhD.

Upcoming books: Airpocalypse, a medical thriller (action taking place in Beijing) 2017; Jesus CRISPR Superstar, a sci-fi -- French title: La Passion du CRISPR (2018).

I love Genomics. Would you rather donate your data, or... your vital organs? Imagine all the people sharing their data...

Audio files on this blog are Windows files ; if you have a Mac, you might want to use VLC (http://www.videolan.org) to read them.

Concernant les fichiers son ou audio (audio files) sur ce blog : ce sont des fichiers Windows ; pour les lire sur Mac, il faut les ouvrir avec VLC (http://www.videolan.org).


Now This Is How You Find Disease Genes

"Bringing individuals' chromosomal variants together."

"Exploring Personal Genomics"

6 billion nucleotides
23 chromosome pairs
~ 2% protein coding
"Significant advances in science are taking place, but translating them into clinical treatments for an array of human diseases is being hampered by public policies that are not aligned with the public good." (Source)

Find the Kindle version of this book on Amazon
"Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable."

Amazon


Apple vs. Google: An mHealth Face-Off

Wearable books?

MIT researchers create wearable books

Health, appiness and "iPochondria"

"CRISPR will one day be used to change the genetic makeup of human embryos."

"Using a recently developed genome-editing technique called CRISPR, a Chinese team has successfully altered two target genes in cynomolgus monkeys, paving the way for the development of monkey models that mimic human diseases. This is the first evidence that CRISPR can work in primates and represents a big advance over previous successes in genetically modifying monkeys, in which genes were inserted randomly into the genome. Only two of the three target genes were modified, and not all cells carry the same modification, indicating more work needs to be done to perfect the timing of the modification. Beyond its significance for biomedical research, the new work raises the possibility that CRISPR will one day be used to change the genetic makeup of human embryos."

"Jekyll-and-Hyde protein determines life and death of cancer cells"

"Jekyll-and-Hyde protein determines life and death of cancer cells"
 

Family hopes genome test will help cure girl's mystery disease

Very impressed by this story.

"When scientists first assembled a draft of the human genome in 2000, they hoped sequencing technology could revolutionize medicine by revealing the genetic underpinnings of all sorts of ailments. Since then, the cost of reading the 3 billion DNA letter pairs that make up a person's genetic blueprint has plummeted from hundreds of millions of dollars to about $1,000. It used to take months; now, technicians can get a read in about a day."

Reading Lilly's fiction right now... Understanding various gene mutations happening in same disease in as much patients as we can: this is how we'll find crucial help curing the disease. Same disease patients will have a lot of genome data sharing work to do... This is the way genome sequencing works when it comes to helping modeling new drugs... If the drug does not target enough gene mutations, the disease will come back...

Find "The Girl They Thought They Never Knew" on Amazon!

MIT 7.00x MOOC: strength in numbers!

https://www.facebook.com/700xIntroToBiology

Was able to find my pic! Thank you,  ! "7.00x The Secret of Life" was indeed a fascinating course... No doubt it will change the course of my life...


Meet e-patient Steve Jobs!



Welcome to the "digital age of biology", in which "the once distinct domains of computer codes and those that program life are beginning to merge, where new synergies are emerging that will drive evolution in radical directions." J. Craig Venter: "Life at the Speed of Light". Here's my first experience of this through ... e-patient Steve Jobs!

"We want public archiving of all data."

Terabyte, Petabyte and Genomic Dataset

"Researchers create embryonic stem cells without embryo."

"Better nanoswitches by integrating double and triple strand DNA"

DNA clamp to grab cancer before it develops!

"The Police Will Soon Be Able To Test DNA In The Field In Just 90 Minutes."

"Would u publish your latest research findings as a Tweet? You can now."


"In the Internet era, research moves from professionals’ labs to amateurs’ homes"

The "Internet of Medical Things" is gradually getting built

"Sadly, we are sitting in prescription medicine darkness, whence there are over 6000 medications and there are genomic data for less than 2% of them. Much more needs to be done for commonly prescribed meds and for those in clinical investigation."

Insightful, brilliant and concise, as usual...

23andFda




Will cancer become a "chronic" disease in one or two decades?


The difference between experience and knowledge in one image

Illumina's Hiseqx10




So this super-duper sequencing machine can be found in Boston (Broad Institute), in NY (NY Genome Center), in Sydney (Garvan Institute of Medical Research), in Seoul -- Korea-based genomic services company Macrogen -- and in Iceland (Decode Genetics)...

Researchers find way to control biological networks in cells with DNA -Could reprogram disease

Wao. "In the digital age of biology, the once distincts domains of computer codes and those that program life are beginning to merge; new synergies are emerging that will drive evolution in radical directions." Geneticist J. Craig Venter, in his stunning and amazing book "Life at the speed of light", is totally right...

Zip code should not be basis for finding trial right for you, it's the molecular basis of your cancer







Diagnosing autism? There is an app for that!

"$1k genome is great, but interpretation? Yes - THAT is the killer app."


http://nextgenseek.com/2014/01/illuminas-jay-flatley-at-pmwc14-get-sequence-of-1-million-cancer-patients-in-next-5-years
 Personalized Medicine World Conferences 2014




The Exposome Sensor-> Smartphone for env't exposure is taking off

Vein Viewer

Who needs the pain of multiple needle sticks because the nurse cannot find the vein? Behold... the vein viewer!


VeinViewer : appareil médical pour voir les veines par Spi0n

Boston Company Developing Synthetic Organs



Man, 30, found dead after 8-hour wait in BX emergency room

List of #HealthIT experts on #Twitter: want to be included?

New educational program for the 117,000 resident and fellow physicians in training

Convergence -> Nanomedicine: Using DNA to deliver nanoparticles

"Realities of data sharing using the genome wars"

"The purpose of this article is to examine one process of data sharing in detail in the hope that the problems and successes can inform the system more generally." 

Realities of data sharing using the genome wars: as case study - an historical perspective and commentary

 ==> Download case study as PDF (15 pages) here.

California to fund research in stem-cell genomics

ScienceWriting Competition with @NatureBiotech opens TODAY

Cambridge nanotech bought by Chinese

J. Craig Venter: "Cool article on data sharing, Celera and the Genome Wars by veteran"

"Advancing the science of genomics"

Acid reflux treatment: pioneering reconstructive natural office surgery

Attacking Cancer With Light-Controlled Bacteria?

The universe of cancer mutations is much bigger than previously thought

Developing mobile software for the visualization and use of Genomic Information

Venter on adrenaline, science and the meaning of life


"The tech companies that mastered design will now need to conquer the entirely different realm of fashion."

"Same disease patients will have a lot of genomic data sharing work to do -- worldwide." Eric Lander, PhD, one of the world’s leading geneticists


"Deadly Medicine: Nazi Eugenics and its Implications Today "

The world's oldest cancer is 11,000 years old -- and contagious



"Scientists have finally unlocked the sequence of the world's oldest surviving cancer — an 11,000-year-old, sexually-transmitted genital cancer that still affects dogs today.
Scientists from the University of Cambridge and the Wellcome Trust Sanger Institute, led by Elizabeth Murchison, published the new research in Science. The cancer first arose in a single dog over 11,000 years ago, and has been passing around among dogs ever since, although scientists didn't know that when they first started out. They simply knew that it was a very old cancer. To get their first hints of its age, they pored through old veterinary literature, and were able to find records of it existing all the way back in 1810."

Read more.

Amazing!!

94% of patients willing to share health information on social media

MonsterHigh Institute of Tech (MIT Salem): Genomic musical hitting Growlway!

This is about a piece of fan art I came up with. I'm 44 years old, I love genomics and Monster High dolls... So.... Guys, this was doomed to happen!

If you could have dinner with someone who is changing how #healthcare works, who would it be and why?

"How Long Have I Got Left?"

"Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. A Book Review."

http://clarksearch.com/regenesis-how-synthetic-biology-will-reinvent-nature-and-ourselves
"Regenesis is a book about synthetic biology, which is written on a semi-layman’s level, well just barely. It is an important subject that many of us don’t realize is happening right now and has been for quite some time. Also I like challenges and the book was a challenge to me to see how much I understood. After each chapter I would say, 'ok, one more down. Whew!' Another reason I finally finished the book is that I like to complete things no matter how long it takes to do so. And frankly the subject is important and relevant to my work as an executive recruiter, who often has to search for scientists with genetics and genomic backgrounds. But also I am a glutton for punishment. I just received from Amazon my copy of Craig Venter’s new book 'Life at the Speed of Light' about his adventure into synthetic biology. I thought it would be 'fun' to compare the two books whenever I finished the Venter book. Let’s just hope it doesn’t take 8 months! Truthfully, I would rather be sitting on a tropical beach reading a thriller, but in the interest of science, I will plug along."

READ MORE

Find the Kindle version on Amazon

Shocking Secrets Of FDA Clinical Trials Revealed

R.I.P. Stethoscope?

Asking the right Q: Can saliva glucose measurements be accurate?

New Genes Are Created From Non-Coding DNA Often, Says Study

"The Startups Saving Health Care"

"The Trillion Dollar Cure"

Study Suggests MicroRNA Panels May Aid in Pancreatic Cancer Diagnoses from Whole Blood Samples

Former Apple CEO backs virtual doctor's office to create the 'consumer era' of medicine

Let’s talk about Genome Music!






http://www.crystalinks.com/genetics.html

What "Patient Centered" Is - And Isn't

Do you follow UCSF Hospitals on Twitter?



"Petition to lift 23andMe FDA ban reaches 10k signatures."


Merci à vous, Jean-Michel Billaut (Billautshow)

Social & political implications are numerous. Meet the world 1st legal cyborg

Better to have a heart attack in Sweden than the UK

Digital comes to medicine

$1k human #genome? OK, now what?

Now what? Connecting the dots between genotype and phenotype...
"The HiSeq X Ten should give us the ability to analyze complete genomic information from huge sample populations,' said Eric Lander, founding director of the Broad Institute and one of the world’s leading geneticists, in a statement. 'Over the next few years, we have an opportunity to learn as much about the genetics of human disease as we have learned in the history of medicine.'"
The race for the $1,000 genome has been won.

"Illumina’s supercomputing machine, which is a combination of ten machines working together and is called the HiSeq X Ten, is available to purchase at a starting price of $10 million. This is too expensive for most labs, but three of these machines have been acquired by Macrogen, The Harvard-MIT Broad Institute in Cambridge, and the Garvan Institute of Medical Research in Australia."
Venturebeat.com January 17, 2014
 ... and don't forget the NY Genome Center!
Un coût divisé par 100.000 :

"La raison d'une telle avancée ? Depuis les années 2005, le séquençage a fait un bond. Une rupture s'est produite. 'Le décryptage s'effectue de façon massivement parallèle sur des puces. Roche, puis Illumina et Life Technologies ont été les pionniers de ces nouvelles méthodes', rappelle le directeur adjoint de l'Institut de génomique. Des brins d'un génome, cassé en morceaux de 100 à 150 bases, se collent sur la puce, où sont fixées des amorces, puis sont lues par une caméra. La performance s'améliore quand la densité de la puce et la vitesse de la lecture optique augmentent. Puis les brins sont assemblés et reconstitués en 23 chromosomes, par calcul informatique, 'par comparaison au génome humain de référence, dont la connaissance s'est nettement affinée depuis le premier génome complet publié en 2003', ajoute Pierre Le Ber. Des années 1970 jusqu'en 2005, la technique enzymatique sélective, élaborée par le Britannique Frederick Sanger, double prix Nobel de chimie, était moins rapide.
'Pour la recherche, c'est, bien sûr, très intéressant. Mais une telle performance est encore plus essentielle pour la génomique clinique afin, par exemple, d'identifier la nature des altérations génétiques qui seraient à l'origine d'un cancer donné, en décryptant l'ADN du malade et celui de sa tumeur. Ce qui peut aider, dans certains cas, le médecin à mieux cibler le traitement', précise le directeur adjoint de l'Institut de génomique."
Le Figaro Sciences - 21 Janvier 2014




Impressive DNA seq studies #schizophrenia-> convergence w/ #autism

Regeneus lines up manufacturer for US CryoShot trial

CryoShot Canine is an allogenic cell therapy for treating osteoarthritis and other musculoskeletal conditions in dogs. It is produced from adipose tissue of a donor animal. Regeneus is currently working on a human version of CryoShot using the same techniques. - See more at: http://lifescientist.com.au/content/biotechnology/news/regeneus-lines-up-manufacturer-for-us-cryoshot-trial-1231691767#sthash.zRdRy6d1.dpuf

CryoShot Canine is an allogenic cell therapy for treating osteoarthritis and other musculoskeletal conditions in dogs. It is produced from adipose tissue of a donor animal. Regeneus is currently working on a human version of CryoShot using the same techniques. - See more at: http://lifescientist.com.au/content/biotechnology/news/regeneus-lines-up-manufacturer-for-us-cryoshot-trial-1231691767#sthash.zRdRy6d1.dpuf
CryoShot Canine is an allogenic cell therapy for treating osteoarthritis and other musculoskeletal conditions in dogs. It is produced from adipose tissue of a donor animal. Regeneus is currently working on a human version of CryoShot using the same techniques. - See more at: http://lifescientist.com.au/content/biotechnology/news/regeneus-lines-up-manufacturer-for-us-cryoshot-trial-1231691767#sthash.zRdRy6d1.dpuf

"Navigating Healthcare Today" - Leonard Kish

How Moore's Law is evolving to make the next wave of semiconductor designs even more disruptive

The Computer Code and Organic Code (DNA) are quite similar
In DNA microchip technology, they keep moving the line...

Researchers discover how heart arrhythmia occurs

Manufacturing Facility to Grow Custom Replacement Tracheas

Innovative: Harnessing the movement of organs to power embedded sensors

Got a #DigitalHealth solution? Add it 2 crowdsourced list of 400+ others

Is there no profit in keeping us well?

Carla N. Berg: There is an increasing cohort of leadership level voices working hard for constructive change in health and medicine-- a prime example being Eric Topol MD of Scripps who has used his several platforms to spread conversations involving the 'creative destruction' of medicine itself (look for his book about same on Amazon) or follow the hashstream #cdom on Twitter and note who contributes.

And for fans of change at a more localized level, see the increasing cohort of articulate docs at places like KevinMD, The HealthCare Blog (THCB), 33 Charts, Wing of Zock, and of course, our own site at participatorymedicine.org.

You are reminding me I need to make a list and share it! But do take heart -- the 'movement' for constructive change in healthcare really is gaining steam ;->
Society for Participatory Medicine (SPM) Group Discussion on LinkedIn
Society for Participatory Medicine (SPM) Group Discussion on LinkedIn


Your entire genome sequenced for 10 USD in 2020?

Why not teach ultrasound in medical school?